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GEM144

CAT: 0931-T62916-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62916-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2487526-28-1
Target
Apoptosis, Others, DNA/RNA Synthesis, HDAC
Related Pathways
Others, Chromatin/Epigenetic, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Apoptosis
Bioactivity
GEM144 is a potent, orally active dual inhibitor of DNA polymerase α (POLA1) and HDAC 11. GEM144 induces p53 acetylation, activates p21, blocks the cell cycle in G1/S phase and induces apoptosis.
Smiles
O(C(C(NO)=O)C)C1=C(C23CC4CC(C2)CC(C3)C4)C=C(C=C1)C5=CC=C(/C=C/C(O)=O)C=C5
Molecular Formula
C28H31NO5
Molecular Weight
461.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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C04944GEM144
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A24023-100GEM144 100mg
A24023-5GEM144 5mg
A24023-50GEM144 50mg

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