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AZ191

CAT: 0931-T6257-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T6257-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1594092-37-1
Target
DYRK
Related Pathways
Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors
Purity
0.9965
Bioactivity
AZ191 (IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.
Smiles
COc1cc(ccc1Nc1nccc(n1)-c1cn(C)c2cnccc12)N1CCN(C)CC1
Molecular Formula
C24H27N7O
Molecular Weight
429.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

AZ191
CAS Number1594092-37-1
PubChem CID72716071
IUPAC NameN-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
Molecular FormulaC24H27N7O
Molecular Weight429.5
XLogP2.7
Topological Polar Surface Area71.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count32
Formal Charge0
Complexity601
SMILES
CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC
InChI
InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
InChIKey
ZYVXTMKTGDARKR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AZ191
CAS: 1594092-37-1
CID: 72716071
Formula: C24H27N7O
MW: 429.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.5
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass429.22770851
Monoisotopic Mass429.22770851
Topological Polar Surface Area71.3 Ų
Heavy Atom Count32
Formal Charge0
Complexity601
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T9461-01AZ194

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CatalogName
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A14314-25AZ191 25mg

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