Products for Research Use Only
RegisterLogin

ALM301

CAT: 0931-T62149-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T62149-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1313439-71-2
Target
Others, Akt
Related Pathways
Others, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling
Bioactivity
ALM301 is a highly specific, orally active AKT inhibitor that acts on AKT1 (IC50: 0.13 μM), AKT2 (IC50: 0.09 μM) and AKT3 (IC50: 2.75 μM) . ALM301 inhibits AKT phosphorylation in vitro and has a regulatory effect on downstream signalling. ALM301 exhibits inhibitory effects on cancer cell proliferation and tumor growth.
Smiles
CCN1C(=O)COc2nc(-c3ccc(cc3)[C@@]3(N)C[C@H](O)C3)c(cc12)-c1ccccc1
Molecular Formula
C25H25N3O3
Molecular Weight
415.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Engasertib

VAD-044 is an allosteric AKT inhibitor developed by Vaderis Therapeutics AG. It is being investigated for the treatment of Hereditary Hemorrhagic Telangiectasia.

CAS Number1313439-71-2
PubChem CID68299673
IUPAC Name6-[4-(1-amino-3-hydroxycyclobutyl)phenyl]-1-ethyl-7-phenylpyrido[2,3-b][1,4]oxazin-2-one
Molecular FormulaC25H25N3O3
Molecular Weight415.5
XLogP2.6
Topological Polar Surface Area88.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity638
SMILES
CCN1C(=O)COC2=C1C=C(C(=N2)C3=CC=C(C=C3)C4(CC(C4)O)N)C5=CC=CC=C5
InChI
InChI=1S/C25H25N3O3/c1-2-28-21-12-20(16-6-4-3-5-7-16)23(27-24(21)31-15-22(28)30)17-8-10-18(11-9-17)25(26)13-19(29)14-25/h3-12,19,29H,2,13-15,26H2,1H3
InChIKey
BPHCAPAOSHZYJY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Engasertib
CAS: 1313439-71-2
CID: 68299673
Formula: C25H25N3O3
MW: 415.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.5
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass415.18959167
Monoisotopic Mass415.18959167
Topological Polar Surface Area88.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity638
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
TMPH-04375-01ALMT1 Protein, Triticum aestivum, Recombinant (His)

Alternative Products

CatalogName
BA8678-5.1ALM301

Popular Products