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VEGFR-2-IN-23

CAT: 0931-T61631-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61631-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2411174-53-1
Target
Others, Apoptosis, VEGFR, MDM-2/p53
Related Pathways
Others, Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors
Bioactivity
VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an IC50 value of 0.34 nM. It demonstrates significant antitumor activity by inducing apoptosis and causing cell cycle arrest at the G1 phase [1].
Smiles
C(#N)C1=C(C=C(NC1=NN)C2=CC3=C(C=C2)C=CC=C3)C4=CC=C(N(=O)=O)C=C4
Molecular Formula
C22H15N5O2
Molecular Weight
381.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Vegfr-2-IN-23
CAS Number2411174-53-1
PubChem CID164517214
IUPAC Name2-hydrazinyl-6-naphthalen-2-yl-4-(4-nitrophenyl)pyridine-3-carbonitrile
Molecular FormulaC22H15N5O2
Molecular Weight381.4
XLogP5.1
Topological Polar Surface Area121
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity620
SMILES
C1=CC=C2C=C(C=CC2=C1)C3=NC(=C(C(=C3)C4=CC=C(C=C4)[N+](=O)[O-])C#N)NN
InChI
InChI=1S/C22H15N5O2/c23-13-20-19(15-7-9-18(10-8-15)27(28)29)12-21(25-22(20)26-24)17-6-5-14-3-1-2-4-16(14)11-17/h1-12H,24H2,(H,25,26)
InChIKey
HKSGWKJRWMNWAL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Vegfr-2-IN-23
CAS: 2411174-53-1
CID: 164517214
Formula: C22H15N5O2
MW: 381.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight381.4
XLogP35.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass381.12257474
Monoisotopic Mass381.12257474
Topological Polar Surface Area121 Ų
Heavy Atom Count29
Formal Charge0
Complexity620
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

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T62763-01VEGFR-2-IN-12
T80872-01VEGFR-2-IN-37
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Alternative Products

CatalogName
HY-149024VEGFR-2-IN-23
HW338207Anti-Human CD309/KDR/VEGFR-2 Antibody (SSS-23)
MBS668224-01VEGFR-2
HW338217-01Anti-Human CD309/KDR/VEGFR-2 Antibody (SSS-23), FITC
MBS1584095-01Anti-Human CD309/KDR/VEGFR-2 Antibody (SSS-23), PerCP
MBS1584093-01Anti-Human CD309/KDR/VEGFR-2 Antibody (SSS-23), PE
FHE16623Anti-Human CD309/KDR/VEGFR-2 Antibody (SSS-23), APC
WH0918U-Blot® Human CD309/KDR/VEGFR-2 Antibody (SSS-23)
BA9059-1VEGFR-2-IN-6
C8539-100VEGFR-2-IN-20

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