D18

• Target:

  Others|||TLR|||PD-1/PD-L1

• Related Pathways:

  Immunology/Inflammation|||Apoptosis|||Cell Cycle/Checkpoint|||Others

• Bioactivity:

  D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively) . It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].

• Smiles:

  N(CCCC)C=1C2=C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)N=C(N)N1

• Molecular Formula:

  C21H28N6

• Molecular Weight:

  364.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2230218-36-5