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D18

CAT: 0931-T61390-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T61390-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2230218-36-5
Target
Others|||TLR|||PD-1/PD-L1
Related Pathways
Immunology/Inflammation|||Apoptosis|||Cell Cycle/Checkpoint|||Others
Bioactivity
D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively) . It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].
Smiles
N(CCCC)C=1C2=C(C=CC(CC3=CC=C(CN(C)C)C=C3)=N2)N=C(N)N1
Molecular Formula
C21H28N6
Molecular Weight
364.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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