P53 Activator 2

CAT: 0931-MF-0138364-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0138364-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2338764-89-7
Target
MDM-2/p53|||Apoptosis|||Others|||DNA/RNA Synthesis
Related Pathways
Apoptosis|||Others|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Bioactivity
P53 Activator 2 (compound 10ah) intercalates into DNA, causing significant double-strand breaks and upregulating the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2/M phase. It induces apoptosis, reduces anti-apoptosis proteins Bcl-2, Bcl-xL, and cyclin B1 levels, and shows anti-proliferative activity against MGC-803 cells with an IC50 of 1.73 ?M. Additionally, p53 Activator 2 exhibits potent anticancer effectiveness in MGC-803 xenograft tumor models [1].
Smiles
N(CCCCN)C=1C2=C(N=C(/C=C/C3=CC=C(N(=O)=O)C=C3)N1)C=CC=C2
Molecular Formula
C20H21N5O2
Molecular Weight
363.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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