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VO-OHPic

CAT: 0931-T61344-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T61344-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
675848-25-6
Target
Others, Autophagy, PTEN, Apoptosis
Related Pathways
Autophagy, Apoptosis, Others, PI3K/Akt/mTOR signaling
Bioactivity
VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM, effectively attenuating apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in models of doxorubicin-induced cardiomyopathy. Additionally, VO-OHPic inhibits autophagy [1] [2] [3].
Smiles
[O-][V]=O.OC(=O)c1ncccc1O.OC(=O)c1ncccc1O
Molecular Formula
C12H10N2O8V
Molecular Weight
361.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C