ARN1468

CAT: 0931-T61256-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T61256-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1381459-14-8

Target

PAI-1, Others

Related Pathways

Metabolism, Others

Bioactivity

ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].

Smiles

NC1=C(C=NN1C1=CC=C(OC(F)(F)F)C=C1)C(=O)C1CCNCC1

Molecular Formula

C16H17F3N4O2

Molecular Weight

354.33

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Related Products

Catalog	Name
T30137-01	ARN14686
T39859	ARN19689
T36468-01	ARN14988

Alternative Products

Catalog	Name
MBS5803961	ARN1468

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