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SEN177

CAT: 0931-T61063-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T61063-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2117405-13-5
Target
Huntingtin, Apoptosis, Beta Amyloid, Glutaminyl Cyclase
Related Pathways
Neuroscience, Apoptosis
Bioactivity
SEN177 shows the potential in the research of Huntington's disease that is a potent inhibitor of glutaminyl cyclase (QPCT) with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL) . The Ki value of SEN177 for human glutaminyl cyclase (hQC) is 20 nM. SEN177 significantly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates [1].
Smiles
Cn1cnnc1C1CCN(CC1)c1ncccc1-c1ccc(F)nc1
Molecular Formula
C18H19FN6
Molecular Weight
338.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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