Sapitinib

• CAS Number :

  848942-61-0

• Target :

  EGFR

• Related Pathways :

  JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Purity :

  0.9983

• Bioactivity :

  Sapitinib (AZD-8931), a reversible, ATP competitive inhibitor of EGFR (IC50=4 nM), ErbB2 (IC50=3 nM) and ErbB3 (IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the ErbB family over MNK1 and Flt.

• Smiles :

  CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC

• Molecular Formula :

  C23H25ClFN5O3

• Molecular Weight :

  473.93

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C