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Sapitinib

CAT: 0931-T6092-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T6092-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
848942-61-0
Target
EGFR
Related Pathways
JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9983
Bioactivity
Sapitinib (AZD-8931), a reversible, ATP competitive inhibitor of EGFR (IC50=4 nM), ErbB2 (IC50=3 nM) and ErbB3 (IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the ErbB family over MNK1 and Flt.
Smiles
CNC(=O)CN1CCC(CC1)Oc1cc2c(Nc3cccc(Cl)c3F)ncnc2cc1OC
Molecular Formula
C23H25ClFN5O3
Molecular Weight
473.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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