Linsitinib

• Target :

  IGF-1R

• Related Pathways :

  Tyrosine Kinase/Adaptors

• Purity :

  0.9992

• Bioactivity :

  OSI-906 (Linsitinib (OSI-906) ) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.

• Smiles :

  NC=1C=2N(C(=NC2C3=CC4=C(C=C3)C=CC(=N4)C5=CC=CC=C5)[C@H]6C[C@@](C)(O)C6)C=CN1

• Molecular Formula :

  C26H23N5O

• Molecular Weight :

  421.49

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  867160-71-2