Linsitinib

• Target:

  IGF-1R

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Purity:

  0.9992

• Bioactivity:

  OSI-906 (Linsitinib (OSI-906) ) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.

• Smiles:

  NC=1C=2N (C (=NC2C3=CC4=C (C=C3) C=CC (=N4) C5=CC=CC=C5) [C@H]6C[C@@] (C) (O) C6) C=CN1

• Molecular Formula:

  C26H23N5O

• Molecular Weight:

  421.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  867160-71-2