Dehydrocorydaline

• Target:

  Autophagy|||Parasite|||PARP|||Caspase|||Bcl-2 Family|||p38 MAPK

• Related Pathways:

  MAPK|||DNA Damage/DNA Repair|||Chromatin/Epigenetic|||Proteases/Proteasome|||Apoptosis|||Autophagy|||Microbiology/Virology

• Purity:

  0.9984

• Bioactivity:

  1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose (IC50= 34.914 ug/mL) . 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.

• Smiles:

  CC1=C2C=3C(=CC(OC)=C(OC)C3)CC[N+]2=CC=4C1=CC=C(OC)C4OC

• Molecular Formula:

  C22H24NO4

• Molecular Weight:

  366.43

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  30045-16-0