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Neferine

CAT: 0931-T5S1097-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T5S1097-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2292-16-2
Target
Autophagy, Apoptosis, NF-κB
Related Pathways
Autophagy, NF-κB, Apoptosis
Purity
0.9975
Bioactivity
1. Neferine ((-) -Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.
Smiles
COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(Oc4cc(C[C@@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc23)cc1
Molecular Formula
C38H44N2O6
Molecular Weight
624.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
FN65588Neferine
HY-N0441RNeferine (Standard)
A14743-10Neferine 10mg
A14743-50Neferine 50mg
A14743-25Neferine 25mg
A14743-100Neferine 100mg
A14743-5Neferine 5mg
AR-N01235-01Biotinylated Neferine
TRC-N389205-25MGO-Biotinyl Neferine

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