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Peimisine

CAT: 0931-T5S0106-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T5S0106-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
19773-24-1
Target
Angiotensin-converting Enzyme (ACE), Apoptosis, RAAS, AChR
Related Pathways
Apoptosis, Neuroscience, Endocrinology/Hormones, Metabolism
Purity
0.998
Bioactivity
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Peimisine can attenuate lung tissue injury (ALI), LDH and MDA amount in ALI mice in a dose dependent manner, it also lower the total protein, total white blood cells, lymphocyte and neutrophilic leukocyte in bronchoalveolar lavage fluid (BALF) ; suggests that peimisine can play a protective role against LPS-induced acute lung injury. 3. Peimisine has the protective effect on the experimental hepatic fibrosis formation, the possible mechanisms are associated with inhibiting fibrogenesis and fibrosis accumulation, and decreasing lipid peroxidation. 4. Peimisine can inhibit angiotensin I converting enzyme activity in a dose-dependent manner, displaying 5 % inhibitory concentration values of 526.5 microM, thus, it may have antihypertensive action.
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C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC(=O)[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C
Molecular Formula
C27H41NO3
Molecular Weight
427.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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