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Isofraxidin

CAT: 0931-T5S0045-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T5S0045-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
486-21-5
Target
TLR, COX, MMP, ERK, p38 MAPK
Related Pathways
Immunology/Inflammation, Proteases/Proteasome, MAPK, Neuroscience
Purity
0.997
Bioactivity
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
Smiles
COc1cc2ccc(=O)oc2c(OC)c1O
Molecular Formula
C11H10O5
Molecular Weight
222.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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