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YZ129

CAT: 0931-T5339Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T5339Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1643120-60-8
Target
Others, Apoptosis, HSP
Related Pathways
Metabolism, Apoptosis, Others, Cytoskeletal Signaling
Bioactivity
YZ129, a glioblastoma inhibitor, targets the HSP90-calcineurin-NFAT pathway by directly binding to heat shock protein 90 (HSP90) and exhibits an IC 50 of 820 nM on NFAT nuclear translocation. It induces cell-cycle arrest at the G2/M phase in GBM cells, leading to apoptosis and inhibiting tumor cell proliferation and migration [1].
Smiles
O=C1C=C(Nc2ccc3cnccc3c2)c2ccccc2C1=O
Molecular Formula
C19H12N2O2
Molecular Weight
300.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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MBS387939-01YZ129
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A13601-1YZ129 1mg
A13601-50YZ129 50mg
A13601-10YZ129 10mg

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