Sugammadex

CAT: 0931-MF-0051040Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0051040Size:5 mg
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CAS Number
343306-71-8
Target
Others
Related Pathways
Others
Bioactivity
Sugammadex is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA) . Sugammadex is a modified ?-cyclodextrin, with a lipophilic core and a hydrophilic periphery. This gamma cyclodextrin has been modified from its natural state by placing eight carboxyl thio ether groups at the sixth carbon positions. These extensions extend the cavity size allowing greater encapsulation of the rocuronium molecule. These negatively charged extensions electrostatically bind to the quaternary nitrogen of the target as well as contribute to the aqueous nature of the cyclodextrin.
Smiles
O[C@@H]1[C@@H](O)[C@@H]2O[C@H]3O[C@H](CSCCC(O)=O)[C@@H](O[C@H]4O[C@H](CSCCC(O)=O)[C@@H](O[C@H]5O[C@H](CSCCC(O)=O)[C@@H](O[C@H]6O[C@H](CSCCC(O)=O)[C@@H](O[C@H]7OC(CSCCC(O)=O)[C@@H](O[C@H]8O[C@H](CSCCC(O)=O)[C@@H](O[C@H]9OC(CSCCC(O)=O)[C@@H](O[C@H]1OC2CSCCC(O)=O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O
Molecular Formula
C72H112O48S8
Molecular Weight
2002.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Alternative Products

CatalogName
RM-S075436-01Sugammadex-S-Sugammadex Dimer
RM-S075426-01Sugammadex-Ss- Sugammadex (Dimer)
MBS5785951Sugammadex
RM-S075465-01Mono Hydroxy Of Sugammadex; Monohydroxy Sugammadex
MBS131932Sugammadex sodium
C11916Sugammadex (sodium)
RM-S075473-01Sugammadex Cylcopropane Impurity
RM-S075470-01Sugammadex Tppo Analogue
RM-S075504-01Sugammadex Impurity 104
RM-S075503-01Sugammadex Impurity 103

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