FM-381

CAT: 0931-MF-0018775-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0018775-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2226521-65-7
Target
JAK
Related Pathways
Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Stem Cells
Purity
0.9933
Bioactivity
FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Smiles
CN(C)C(=O)C(=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1)\C#N
Molecular Formula
C24H24N6O2
Molecular Weight
428.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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