FM-381

• Target:

  JAK

• Related Pathways:

  Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Stem Cells

• Purity:

  0.9933

• Bioactivity:

  FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

• Smiles:

  CN (C) C (=O) C (=C\c1ccc (o1) -c1nc2cnc3[nH]ccc3c2n1C1CCCCC1) \C#N

• Molecular Formula:

  C24H24N6O2

• Molecular Weight:

  428.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2226521-65-7