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Prunetin

CAT: 0931-T4S0878-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T4S0878-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
552-59-0
Target
ERK, NF-κB, Dehydrogenase
Related Pathways
Metabolism, MAPK, NF-κB
Purity
0.9843
Bioactivity
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
Smiles
COc1cc(O)c2c(c1)occ(-c1ccc(O)cc1)c2=O
Molecular Formula
C16H12O5
Molecular Weight
284.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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