Glaucocalyxin A

• Target :

  Apoptosis|||Akt|||Caspase|||PI3K

• Related Pathways :

  Apoptosis|||Proteases/Proteasome|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling

• Purity :

  0.998

• Bioactivity :

  1. Glaucocalyxin A (Leukamenin F) -SBE-?-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase C?2, the signaling events in collagen receptor GP? pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.

• Smiles :

  [H][C@@]12CC[C@@H]3[C@@H](O)[C@@]1([C@H](O)C[C@]1([H])C(C)(C)C(=O)CC[C@@]21C)C(=O)C3=C

• Molecular Formula :

  C20H28O4

• Molecular Weight :

  332.43

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  79498-31-0