Glaucocalyxin A

• Target:

  Apoptosis|||Akt|||Caspase|||PI3K

• Related Pathways:

  Apoptosis|||Proteases/Proteasome|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling

• Purity:

  0.998

• Bioactivity:

  1. Glaucocalyxin A (Leukamenin F) -SBE-?-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase C?2, the signaling events in collagen receptor GP? pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.

• Smiles:

  [H][C@@]12CC[C@@H]3[C@@H] (O) [C@@]1 ([C@H] (O) C[C@]1 ([H]) C (C) (C) C (=O) CC[C@@]21C) C (=O) C3=C

• Molecular Formula:

  C20H28O4

• Molecular Weight:

  332.43

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  79498-31-0