WHI-P97

• Target:

  JAK

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||Stem Cells|||JAK/STAT signaling|||Chromatin/Epigenetic

• Purity:

  0.9993

• Bioactivity:

  WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.

• Smiles:

  COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC

• Molecular Formula:

  C16H13Br2N3O3

• Molecular Weight:

  455.1

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  211555-05-4