WHI-P97

CAT: 0931-T4657-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T4657-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
211555-05-4
Target
JAK
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||Stem Cells|||JAK/STAT signaling|||Chromatin/Epigenetic
Purity
0.9993
Bioactivity
WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.
Smiles
COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC
Molecular Formula
C16H13Br2N3O3
Molecular Weight
455.1
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS386878-01WHI-P97
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A11608-5WHI-P97 5mg
A11608-50WHI-P97 50mg
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M22900-01WHI-P97 HCl 211555-05-4 (free base)

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