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RO1138452

CAT: 0931-T4436-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T4436-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
221529-58-4
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein, Immunology/Inflammation
Purity
0.9934
Bioactivity
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3) . It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].
Smiles
CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1
Molecular Formula
C19H23N3O
Molecular Weight
309.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BA5698-50RO1138452
HY-108912R-01RO1138452 (Standard)

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