Niemann Pick C2 Recombinant Rabbit Monoclonal Antibody [PSH05-52]

Niemann Pick C2 Recombinant Rabbit Monoclonal Antibody [PSH05-52]

• Description: The epididymal secretory protein E1, also known as NPC2 (Niemann-Pick intracellular cholesterol transporter 2), is one of two main lysosomal transport proteins that assist in the regulation of cellular cholesterol by exportation of LDL-derived cholesterol from lysosomes. Lysosomes have digestive enzymes that allow it to break down LDL particles to LDL-derived cholesterol once the LDL particle is engulfed into the cell via receptor mediated endocytosis. NPC2 works cooperatively with the NPC1 protein to facilitate the exportation of LDL-derived cholesterol out of the lysosome to regulate the concentrations of lipids and cholesterol in the body. Epididymal secretory protein E1 is a protein associated with Niemann-Pick disease, type C, which is one of the 3 types of the Niemann-Pick diseases (Type A, B, and C). This disease can lead to an over accumulation of cholesterol and lipids in different types of tissues, including the brain. It is caused by a mutation in the NPC2 gene that impairs the body's ability to transport lipids or cholesterol intracellularly.
• Product Name Alternative: EDDM1 antibody Epididymal protein 1 antibody Epididymal secretory protein antibody Epididymal secretory protein E1 antibody hE1 antibody Human epididymis-specific protein 1 antibody Niemann-Pick disease type C2 antibody Niemann-Pick disease type C2 protein antibody NPC intracellular cholesterol transporter 2 antibody NPC2 antibody NPC2_HUMAN antibody Tissue specific secretory protein antibody
• Abbreviation: NPC2, HE1
• CAS Number: 9000-83-3
• Swiss Prot: P61916 Human, Q9Z0J0 Mouse,
• Cellular Locus: Secreted, Endoplasmic reticulum, Lysosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Niemann Pick C2 aa 1-151 / 151.
• Isotype: IgG
• Clone: PSH05-52
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HepG2 cell lysate, HEK-293 cell lysate, RAW264.7 cell lysate, C2C12 cell lysate, C6 cell lysate, mouse kidney tissue lysate, mouse spleen tissue lysate, rat kidney tissue lysate, rat spleen tissue lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:5,000 ;IHC-P: 1:100,000-1:300,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 17 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes