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CIL56

CAT: 0931-T4309-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T4309-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
300802-28-2
Target
Ferroptosis, ROS
Related Pathways
Immunology/Inflammation, Apoptosis
Purity
0.9991
Bioactivity
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS) . It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.
Smiles
ON=C1c2cc(ccc2-c2ccc(cc12)S(=O)(=O)N1CCCCC1)S(=O)(=O)N1CCCCC1
Molecular Formula
C23H27N3O5S2
Molecular Weight
489.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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