Endoxifen

CAT: 0931-T4281-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
CAT#:0931-T4281-01Size:1 mL - 10 mM (in DMSO)
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
110025-28-0
Target
Drug Metabolite|||Cytochromes P450|||Estrogen/progestogen Receptor|||Parasite|||Estrogen Receptor/ERR|||Aromatase
Related Pathways
Endocrinology/Hormones|||Microbiology/Virology|||Metabolism
Purity
>99.99%
Bioactivity
(E/Z) -Endoxifen ((E/Z) -Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.
Smiles
CC\C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1
Molecular Formula
C25H27NO2
Molecular Weight
373.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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