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AZD3759 hydrochloride

CAT: 0931-T4249-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T4249-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1626387-81-2
Target
Apoptosis, EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis
Purity
0.9962
Bioactivity
AZD3759 (hydrochloride) is an effective, orally active and central nervous system-penetrant EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.2/0.3/0.2 nM for EGFR (L858R) /EGFR (wt) /EGFR (exon 19Del) .
Smiles
C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C.Cl
Molecular Formula
C22H24Cl2FN5O3
Molecular Weight
496.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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