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(-) - (S) -B-973B

CAT: 0804-HY-114269-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114269-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) - (S) -B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity[1].
CAS Number
2244989-34-0
Product Name Alternative
BRD6125, Sch 21420 (sulfate)
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_-_-_S_-B-973B.html
Purity
99.22
Solubility
DMSO : 67.5 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C1=NC(N2CCN(C3=NC=CC=C3)CC2)=CN=C1)C)CCC4=CC=C(F)C(F)=C4
Molecular Formula
C24H26F2N6O
Molecular Weight
452.50
References & Citations
[1]Garai S, et al. B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation. ACS Med Chem Lett. 2018 Oct 11;9 (11) :1144-1148.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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