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SC144 hydrochloride

CAT: 0931-T41260Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T41260Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
917497-70-2
Target
Apoptosis, Interleukin, Others
Related Pathways
Others, Immunology/Inflammation, Apoptosis
Bioactivity
SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation (S782) and deglycosylation, impedes Stat3 phosphorylation and nuclear translocation, and suppresses the expression of downstream target genes. Furthermore, SC144 hydrochloride effectively induces apoptosis in human ovarian cancer cells [1].
Smiles
Cl.O=C(NNC1=NC=2C=C(F)C=CC2N3C=CC=C13)C4=NC=CN=C4
Molecular Formula
C16H12ClFN6O
Molecular Weight
358.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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