Products for Research Use Only
RegisterLogin

ND1-YL2

CAT: 0931-T41146Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T41146Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
ND1-YL2 is a peptide-based PROTAC®Degrader of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1) . ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a linker to a tetrapeptide that binds UBR box domains. Upon ternary complex formation, SRC-1 is polyubiquitinated and subsequently degraded via the N-degron pathway. This Degrader induces dose-dependent degradation of SRC-1 in the MDA-MB-231 triple negative breast cancer cell line (DC50 = 10 μM), and binds to the PAS-B domain of SRC-1 (Ki = 320 nM) . ND1-YL2 inhibits MDA-MB-231 cell migrationin vitro, and suppresses metastasis of MDA-MB-231 cellsin vivo.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
TMAB-09075-01Anti-MT-ND1 Antibody (5V968)
TMAB-09074-01Anti-MT-ND1 Polyclonal Antibody

Alternative Products

CatalogName
GTR19037136ND1-YL2
sc-90634-PRCyclin YL2 (h) -PR
sc-90634Cyclin YL2 siRNA (h)
sc-90634-VCyclin YL2 shRNA (h) Lentiviral Particles
sc-90634-SHCyclin YL2 shRNA Plasmid (h)
325355-01ND1
A02292-1Anti-ND1/MT-ND1 Antibody
311238FLO-YL2/NL/750X150 Floor Signs
143501B30-R10000-YL2 AF Systems Consumables
AP01487PU-NMT ND1 (ND1) Rabbit Polyclonal Antibody

Popular Products