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KG5

CAT: 0931-T41003-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T41003-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
877874-85-6
Target
PDGFR, c-Kit, FLT, Raf
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, MAPK
Purity
0.9832
Bioactivity
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.
Smiles
CSc1nc(N)cc(Oc2ccc(cc2)-c2nnc(Nc3cccc(c3)C(F)(F)F)[nH]2)n1
Molecular Formula
C20H16F3N7OS
Molecular Weight
459.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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