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NSC 23766

CAT: 0931-T40848Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T40848Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
733767-34-5
Target
Rho, Ras, AChR
Related Pathways
MAPK, Neuroscience, Cell Cycle/Checkpoint, GPCR/G Protein
Purity
0.9949
Bioactivity
NSC 23766 is a Rac1 GTPase inhibitor that inhibits Rac1 activation by targeting guanine nucleotide exchange factors (GEFs), while it has no inhibitory effect on the closely related targets Cdc42 and RhoA, affecting the cell cycle and inhibiting cell proliferation in a dose-dependent manner. It also regulates endothelial NO synthase expression and endothelial function, and inhibits platelet aggregation and γ-secretase activity.NSC23766 competitively inhibits M2 muscarinic acetylcholine receptor (M2 mAChR) -induced Rac1 activation in neonatal rat cardiomyocytes.
Smiles
N=1C(=NC(=CC1NC=2C=CC=3N=C(C=C(N)C3C2)C)C)NC(C)CCCN(CC)CC
Molecular Formula
C24H35N7
Molecular Weight
421.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-15723-01NSC 23766
MBS130219-01NSC-23766
256051-01NSC 23766 discontinued
A12546-5NSC 23766 5mg
A12546-2NSC 23766 2mg
M10603-01NSC 23766 trihydrochloride
A12546-25NSC 23766 25mg
A12546-10NSC 23766 10mg

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