NH-3

• Target :

  Thyroid hormone receptor (THR)

• Related Pathways :

  Endocrinology/Hormones

• Purity :

  0.994

• Bioactivity :

  NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

• Smiles :

  CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O

• Molecular Formula :

  C28H27NO6

• Molecular Weight :

  473.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  447415-26-1