NH-3

• Target:

  Thyroid hormone receptor (THR)

• Related Pathways:

  Endocrinology/Hormones

• Purity:

  0.994

• Bioactivity:

  NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

• Smiles:

  CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O

• Molecular Formula:

  C28H27NO6

• Molecular Weight:

  473.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  447415-26-1