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KML29

CAT: 0931-T4052-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
CAT#:0931-T4052-01Size:1 mL - 10 mM (in DMSO)
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1380424-42-9
Target
Lipase|||MAGL
Related Pathways
Metabolism
Purity
0.9865
Bioactivity
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM) . It has not inhibitory for FAAH (IC50 > 50 ?M) . It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 ?M, AEA) .
Smiles
OC(C1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)(c1ccc2OCOc2c1)c1ccc2OCOc2c1
Molecular Formula
C24H21F6NO7
Molecular Weight
549.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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