8-Aminoadenosine

• Target:

  DNA/RNA Synthesis|||Others|||Akt|||Apoptosis|||Autophagy|||mTOR

• Related Pathways:

  DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling|||Others|||Autophagy|||Apoptosis|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling

• Bioactivity:

  8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. It also obstructs Akt/mTOR signaling, inducing autophagy and apoptosis in a p53-independent manner. Its significant antitumor activity underscores its therapeutic potential.

• Smiles:

  NC=1N(C=2C(N1)=C(N)N=CN2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

• Molecular Formula:

  C10H14N6O4

• Molecular Weight:

  282.26

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3868-33-5