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T-2513

CAT: 0931-T40365Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T40365Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
288247-87-0
Target
Others, DNA/RNA Synthesis, Topoisomerase
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others
Bioactivity
T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis.
Smiles
CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCCCN)cc12
Molecular Formula
C25H27N3O5
Molecular Weight
449.507
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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