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Cambinol

CAT: 0931-T4019-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T4019-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
14513-15-6
Target
Sirtuin, Apoptosis, Phospholipase
Related Pathways
Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair, Metabolism
Purity
0.9983
Bioactivity
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
Smiles
Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1
Molecular Formula
C21H16N2O2S
Molecular Weight
360.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS3607300-01Cambinol
HY-100732R-01Cambinol (Standard)
A12381-5Cambinol 5mg
A12381-50Cambinol 50mg
A12381-2Cambinol 2mg
A12381-1Cambinol 1mg
A12381-500Cambinol 500mg
A12381-25Cambinol 25mg
A12381-100Cambinol 100mg
A12381-10Cambinol 10mg

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