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Juglone

CAT: 0931-T4010-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T4010-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
481-39-0
Target
NF-κB, Apoptosis, TLR, DNA/RNA Synthesis, Antibacterial
Related Pathways
NF-κB, DNA Damage/DNA Repair, Microbiology/Virology, Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint
Purity
0.9924
Bioactivity
Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM) . Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
Smiles
Oc1cccc2C(=O)C=CC(=O)c12
Molecular Formula
C10H6O3
Molecular Weight
174.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

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sc-202675Juglone
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HY-N102002,7-Dimethoxy-6- (1-acetoxyethyl) juglone

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