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β, β-Dimethylacrylshikonin

CAT: 0931-T3S2344-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T3S2344-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
24502-79-2
Target
HIF/HIF Prolyl-Hydroxylase, ERK, Gamma-secretase, Bcl-2 Family, Apoptosis, NO Synthase
Related Pathways
Neuroscience, Metabolism, Stem Cells, MAPK, Chromatin/Epigenetic, Immunology/Inflammation, Proteases/Proteasome, Apoptosis
Purity
0.9997
Bioactivity
1. β, β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H (22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
Smiles
O=C1C=2C(C(=O)C=C1[C@H](OC(C=C(C)C)=O)CC=C(C)C)=C(O)C=CC2O
Molecular Formula
C21H22O6
Molecular Weight
370.396
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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