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MS33

CAT: 0931-T39975Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T39975Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2407449-11-8
Target
Others, Histone Methyltransferase, PROTACs
Related Pathways
PROTAC, Chromatin/Epigenetic, Others
Bioactivity
MS33 is a highly effective degrader of the WDR5 protein, exhibiting Kd values of 870 nM and 120 nM for VCB and WDR5, respectively. It induces degradation of WDR5 through an E3 ligase VHL-mediated and proteasome-dependent mechanism. MS33 holds promise for furthering research in the field of acute myeloid leukemia.
Smiles
CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCN(CCNC(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)CC2)c1
Molecular Formula
C64H84F3N11O7S
Molecular Weight
1208.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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