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XZ739

CAT: 0931-T39909-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T39909-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2365172-19-4
Target
PROTACs, Apoptosis, Bcl-2 Family
Related Pathways
Apoptosis, PROTAC
Bioactivity
XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-mediated apoptosis.
Smiles
CN(CCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(CC2=C(CCC(C)(C)C2)c2ccc(Cl)cc2)CC1 |t:81|
Molecular Formula
C65H76ClF3N8O12S3
Molecular Weight
1349.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BA2913-1XZ739

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