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Su1498

CAT: 0931-T3980-07Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T3980-07Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
168835-82-3
Target
VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
>99.99%
Bioactivity
Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
Smiles
CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O
Molecular Formula
C25H30N2O2
Molecular Weight
390.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

SU 1498

SU1498 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enoic acid with the amino group of 3-phenylpropylamine. It has a role as a vascular endothelial growth factor receptor antagonist. It is a secondary carboxamide, a nitrile, a monocarboxylic acid amide, a member of phenols and an enamide.

CAS Number168835-82-3
PubChem CID5941539
IUPAC Name(E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide
Molecular FormulaC25H30N2O2
Molecular Weight390.5
XLogP5.8
Topological Polar Surface Area73.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Heavy Atom Count29
Formal Charge0
Complexity577
SMILES
CC(C)C1=CC(=CC(=C1O)C(C)C)/C=C(\C#N)/C(=O)NCCCC2=CC=CC=C2
InChI
InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChIKey
JANPYFTYAGTSIN-FYJGNVAPSA-N
Chemical Structure
2D Structure
2D structure of SU 1498
CAS: 168835-82-3
CID: 5941539
Formula: C25H30N2O2
MW: 390.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight390.5
XLogP35.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass390.230728204
Monoisotopic Mass390.230728204
Topological Polar Surface Area73.1 Ų
Heavy Atom Count29
Formal Charge0
Complexity577
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C11984SU1498
A12472-2SU1498 2mg
A12472-100SU1498 100mg
A12472-50SU1498 50mg
A12472-10SU1498 10mg
A12472-25SU1498 25mg
A12472-5SU1498 5mg
A12472-1SU1498 1mg
A12472-10mM-DSU1498 10mM * 1mL in DMSO

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