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Emedastine

CAT: 0931-T3979-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T3979-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
87233-61-2
Target
Histamine Receptor
Related Pathways
Immunology/Inflammation, GPCR/G Protein, Neuroscience
Purity
0.9776
Bioactivity
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.
Smiles
CCOCCn1c(nc2ccccc12)N1CCCN(C)CC1
Molecular Formula
C17H26N4O
Molecular Weight
302.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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