RegisterLogin

GSK973

CAT: 0931-T39601Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T39601Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
2138473-38-6
Target
Epigenetic Reader Domain|||Others
Related Pathways
Others|||Chromatin/Epigenetic
Bioactivity
GSK973 is a highly selective and orally bioavailable inhibitor that targets the second bromodomains (BD2s) of the BET family. It exhibits a pIC 50 of 7.8 and a pK d of 8.7 specifically for BRD4 BD2. Additionally, GSK973 demonstrates a remarkable selectivity of 1600-fold for BRD4 BD2 over BRD4 BD1. Moreover, it displays good potency against BRD2 BD2, BRD3 BD2, and BRDT BD2, with pIC 50 ranging from 7.4 to 7.8 and pK d ranging from 8.3 to 8.5.
Smiles
[H][C@@]12COC[C@]1([H])[C@H]2NC(=O)c1cc2[C@@H]([C@@H](CF)Oc2c(c1)C(=O)NC)c1ccccc1
Molecular Formula
C23H23FN2O4
Molecular Weight
410.445
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T27498-01GSK983
T5054-01GSK963
T27491-01GSK730
T70015-01GSK563
T25469-01GSK223
T3537-01GSK583
T88543-01GSK878
T1775-01GSK503
T25470-01GSK926
T79017-01GSK737

Alternative Products

CatalogName
BA4729-10GSK973
HY-138563A-01(2R,3R) -GSK973

Popular Products