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Phellopterin

CAT: 0931-T3927-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T3927-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2543-94-4
Target
PPAR, Sirtuin, TLR, PKC, PI3K, HIV Protease, Apoptosis, Akt, ERK, GABA Receptor, Integrin, STAT
Related Pathways
Chromatin/Epigenetic, Membrane transporter/Ion channel, JAK/STAT signaling, Neuroscience, Stem Cells, MAPK, Apoptosis, Proteases/Proteasome, Microbiology/Virology, Metabolism, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair, Immunology/Inflammation, Cytoskeletal Signaling
Purity
0.9999
Bioactivity
Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.
Smiles
COc1c2ccoc2c(OCC=C(C)C)c2oc(=O)ccc12
Molecular Formula
C17H16O5
Molecular Weight
300.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C