Products for Research Use Only
RegisterLogin

Tunlametinib

CAT: 0931-T39220-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T39220-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1801756-06-8
Target
Ras, MEK, Kras
Related Pathways
MAPK
Purity
0.9872
Bioactivity
Tunlametinib is a highly selective, orally bioavailable small molecule inhibitor of MEK1 and MEK2 kinases with a reported IC50 value of 1.9 nM for MEK1. Tunlametinib exerts its antitumor effects by blocking the oncogenic RAS-RAF-MEK-ERK signaling pathway, thereby inducing tumor cell cycle arrest and promoting apoptosis, Tunlametinib demonstrates strong inhibitory activity against various RAS/RAF-mutant cancer cells such as those harboring BRAF V600E or KRAS G12C mutations, shows synergistic effects in combination with BRAF/KRASG12C/SHP2 inhibitors and Docetaxel, and is used in targeted therapy for RAS/RAF-driven cancers including melanoma, colorectal cancer, and non-small cell lung cancer (NSCLC) .
Smiles
O=C(NOCCO)C1=CC=2SC=NC2C(F)=C1NC3=CC=C(I)C=C3F
Molecular Formula
C16H12F2IN3O3S
Molecular Weight
491.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-132844-01Tunlametinib
A24217-10Tunlametinib (HL-085) 10mg
A24217-5Tunlametinib (HL-085) 5mg
A24217-100Tunlametinib (HL-085) 100mg
A24217-50Tunlametinib (HL-085) 50mg

Popular Products