PB28

CAT: 0931-MF-0152672Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0152672Size:25 mg
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CAS Number
172906-90-0
Target
Others|||Apoptosis|||Sigma receptor|||SARS-CoV
Related Pathways
Apoptosis|||Others|||GPCR/G Protein|||Microbiology/Virology
Bioactivity
PB28 is a cyclohexylpiperazine derivative that functions as a potent and highly selective agonist of the sigma 2 (?2) receptor, exhibiting a Ki (binding affinity) of 0.68 nM. At the same time, PB28 acts as an antagonist of the sigma 1 (?1) receptor, with a Ki of 0.38 nM. PB28 demonstrates a lower affinity for other receptors. It effectively inhibits electrically evoked twitch in both the guinea pig bladder (EC50 value of 2.62 ?M) and ileum (EC50 value of 3.96 ?M) . Moreover, PB28 exhibits the ability to modulate protein-protein interaction between SARS-CoV-2 and human cells. Additionally, PB28 triggers caspase-independent apoptosis and possesses significant antitumor activity.
Smiles
COc1cccc2C(CCCN3CCN(CC3)C3CCCCC3)CCCc12
Molecular Formula
C24H38N2O
Molecular Weight
370.581
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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