Uzansertib

• Target:

  Pim|||Others

• Related Pathways:

  Chromatin/Epigenetic|||Others|||JAK/STAT signaling

• Bioactivity:

  Uzansertib (INCB053914) is a potent ATP-competitive pan-PIM kinase inhibitor. It exhibits exceptional inhibitory activity against PIM1, PIM2, and PIM3 with IC50 values of 0.24 nM, 30 nM, and 0.12 nM, respectively. Furthermore, Uzansertib demonstrates significant anti-proliferative effects against an assorted range of hematologic tumor cell lines.

• Smiles:

  C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CC[C@@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F

• Molecular Formula:

  C26H26F3N5O3

• Molecular Weight:

  513.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1620012-39-6