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CYH33

CAT: 0931-T38978Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T38978Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1494684-28-4
Target
Others, PI3K
Related Pathways
PI3K/Akt/mTOR signaling, Others
Bioactivity
CYH33, an orally active and highly selective PI3Kα inhibitor, demonstrates specificity with IC50 values of 5.9 nM for the α isoform, 598 nM for β, 78.7 nM for δ, and 225 nM for γ. It effectively inhibits Akt and ERK phosphorylation and induces substantial G1 phase arrest in breast cancer and non-small cell lung cancer (NSCLC) cells, showcasing potent activity against solid tumors.
Smiles
COC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F
Molecular Formula
C24H29F3N8O5S
Molecular Weight
598.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
M12071-01CYH33
MBS5799537CYH33 methanesulfonate
HY-123938ACYH33 (methanesulfonate)

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