ADTL-EI1712

CAT: 0931-MF-0062059-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0062059-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2414916-45-1
Target
Others|||ERK
Related Pathways
MAPK|||Others
Bioactivity
ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively) .1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 ?M. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 ?M, respectively) . It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a dose of 50 mg/kg per day.
Smiles
C(N)(=O)C=1C2=C(SC1NC(=O)C3=C(Cl)C=CC=C3)CN(C(NC4=C(Cl)C=CC=C4)=S)CC2
Molecular Formula
C22H18Cl2N4O2S2
Molecular Weight
505.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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