R-8507

• Target:

  I?B/IKK|||Others|||Interleukin|||TNF|||RIP kinase

• Related Pathways:

  Apoptosis|||Immunology/Inflammation|||Others|||NF-?B

• Bioactivity:

  R-8507 is a small molecule antagonist of the TNF-? type 1 receptor (TNF-?RI) . It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-? and IL-1? with EC50 values of 2.45 and 3.79 ?M, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-?RI with receptor interacting protein 1 (RIP1) and TNF-?R-associated death domain protein (TRADD), preventing internalization of the receptor complex.

• Smiles:

  FC(F)(F)C1=NC2=CC=CC=C2N2C(=NN=C12)C1=CC=C(Cl)C=C1

• Molecular Formula:

  C16H8ClF3N4

• Molecular Weight:

  348.71

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  338773-13-0